Sandy Pantz is a character in Maniac Mansion, a cheerleader and girlfriend of Dave Miller. She was kidnapped by Dr. Fred and taken to the lab in the basement of the mansion. There, the evil Meteor has plans to remove her brains as part of its plan for world domination. The rescue of Sandy from the mansion is the main plot of Maniac Mansion. She makes an appearance in Thimbleweed Park as a waitress at S and D's diner.

Dr. Fred's line to Sandy with "getting her pretty brains sucked out" was thought gruesome for the NES version of Maniac Mansion, thus it was changed to simply "removed".[1]